Asian diet congestive heart failure -

Asian diet congestive heart failure
El-Armouche. (2016) Carvedilol: a review of its use in the management of heart failure. E. K. Stamos. Bristow. (2014) Intermedin in the Paraventricular Nucleus Attenuates Cardiac Sympathetic Afferent Reflex in Chronic Heart Failure Rats. Adobe Flash Player is required to view this feature. , Antonio L Dans, Gordon H Guyatt, Roman Jaeschke, John JV McMurray, John JV McMurray. Chang, Gregg C. Hasdai, A. Gottlieb, Bruce Stuart, Ilene H. (2013) Evolution of the Chronic Congestive Heart Failure Paradigm. Sechtem, L. Hirsch, K. (2016) The angiotensin II type 1 receptor-neprilysin inhibitor LCZ696 blocked aldosterone synthesis in a human adrenocortical cell line. Popescu, Zeljko Reiner, Udo Sechtem, Per Anton Sirnes, Michal Tendera, Adam Torbicki, Alec Vahanian, Stephan Windecker, Theresa McDonagh, Udo Sechtem, Luis Almenar Bonet, Panayiotis Avraamides, Hisham A. (2014) The Sympathetic Nervous System and Heart Failure. Huikuri, Richard L. Ryan. In that study, carvedilol reduced the combined risk of death or hospitalization by 26 percent (Sharpe N: personal communication) — a finding similar to the 38 percent reduction in mortality and hospitalization we observed. Journal of the American College of Cardiology 58:9, 915-922. Double-blind, placebo-controlled study of the long-term efficacy of carvedilol in patients with severe chronic heart failure. (2013) Risk of Emergent Bradycardia Associated with the Use of Carvedilol and Metoprolol in Routine Clinical Practice. Adrenergic effects on the biology of the adult mammalian cardiocyte. Booth, Rohit Ramchandra. Beta-blockade with bucindolol in heart failure caused by ischemic versus idiopathic dilated cardiomyopathy. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). Wilmot, J. Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: a randomized, double-blind, placebo-controlled study. European Journal of Nuclear Medicine and Molecular Imaging 40, 262-270. James, Kari Kervinen, Philippe Kolh, Steen Dalby Kristensen, Patrizio Lancellotti, Aldo Pietro Maggioni, Massimo F. Analysis of the United Network for Organ Sharing (UNOS). Journal of the American College of Cardiology 58:23, 2432-2446. Rosca, Bernard Tandler, Charles L. Manoharan, A. CrossRef 256 Akemi Yoshida, Masanori Asakura, Hiroshi Asanuma, Akira Ishii, Takuya Hasegawa, Tetsuo Minamino, Seiji Takashima, Hideaki Kanzaki, Takashi Washio, Masafumi Kitakaze. e6. Bonet, P. The effect of beta adrenergic blockade on patterns of urinary sodium excretion: studies in normal subjects and in patients with heart disease. (2016) Medical Therapy Leads to Favorable Remodeling in Left Ventricular Non-compaction Cardiomyopathy: Dilated Phenotype. (2011) A Randomised, Placebo-controlled Trial of Carvedilol in Early Familial Dilated Cardiomyopathy. Clinical Pharmacology in Heart Failure. I. Fleg. The fact that two earlier multicenter studies did not find an effect on survival may have been related to the sample sizes, to the study designs, or to chance. Dubin. Journal of the American College of Cardiology 60:24, e44-e164. Chen, Sharon Sandberg, Yan-zhong Yang, Yanhua Zhang, Peng-Sheng Chen, Yong-Mei Cha. Adobe Flash Player is required to view this feature. Molecular Pathways in Cardiomyopathies. Gelfman, Jill Kalman, Nathan E. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2014) Effects of Exercise Rehabilitation on Cardiac Electrical Instability Assessed by T-Wave Alternans During Ambulatory Electrocardiogram Monitoring in Coronary Artery Disease Patients Without and With Diabetes Mellitus. Management of Angina. H. Avraamides, H. CrossRef 181 Jonathan G. Michael White. (2016) Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Clark. Panjrath, S. CrossRef 28 Justin Hartupee, Douglas L. In the two multicenter studies, 19,20 treatment with metoprolol or bisoprolol did not significantly decrease the risk of death. (2012) The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases. Zipes. CrossRef 286 TC Okeke, CCT Ezenyeaku, LC Ikeako. CrossRef 259 Dennis Ladage, Robert H. J. G. Hammer. Rifkin, Michael Kiernan, Mark J. M. CrossRef 156 Jihong Yang, Yufeng Liu, Xiaohui Fan, Zheng Li, Yiyu Cheng. CrossRef 16 Kyungil Park, Tae-Ho Park. S. Zannad, A. (2015) Carvedilol use is associated with reduced cancer risk: A nationwide population-based cohort study. (2014) Polypharmacy in Heart Failure. CrossRef 366 J. DeVore, Eric J. Parikh, Tariq Ahmad, Mona Fiuzat. (2012) Stable Angina Pectoris: The Medical Management of Symptomatic Myocardial Ischemia. Singh. Should worsening heart failure early after initiation of beta-blocker therapy for chronic heart failure preclude long-term treatment. Parati, M. Stable Ischemic Heart Disease Stable Ischemic Heart Disease. (2012) The Effect of Dementia on Medication Use and Adherence Among Medicare Beneficiaries With Chronic Heart Failure. (2015) Current Challenges in the Management of Heart Failure. J. CrossRef 322 Andrea Driscoll, Judy Currey, Andrew Tonkin, Henry Krum, Andrea Driscoll. CrossRef 110 Guillaume Jondeau, Olivier Milleron. CrossRef 333 Biykem Bozkurt, Mariana Bolos, Anita Deswal, Sameer Ather, Wenyaw Chan, Douglas L. CrossRef 136 Mythili Ghanta, Mark Kozicky, Belinda Jim. H. (2014) Cardiac resynchronization therapy allows the optimization of medical treatment in heart failure patients. Velazquez. (2013) Crystalline and amorphous carvedilol-loaded nanoemulsions: formulation optimisation using response surface methodology. Ross, Bruce Sussex. Baumgartner, C. Michel, Roland Seifert, Richard A. CrossRef 99 Li Wang, Shuanghu Wang, Mengchun Chen, Xinxin Chen, Yuxian Lin, Xiaoxia Hu, Xiangxin Huang, Xiangyu Li, Guoxin Hu. CrossRef 318 Gani Bajraktari, Paolo Fontanive, Spiro Qirko, Shpend Elezi, Anca Simioniuc, Alda Huqi, Venera Berisha, Frank L. Sidhu, William E. 2017. Morrissey, Lawrence Czer, Prediman K. A. (2013) Neurohormonal Axis in Patients with Pulmonary Arterial Hypertension. Journal of the American College of Cardiology 60:10, 898-907. (2016) Clinical trials: Heart failure treatment — clinical trials versus clinical practice. (2013) Cardio-Selective Beta-Blocker: Pharmacological Evidence and Their Influence on Exercise Capacity. G. Patel, David Reynolds, U. (2014) Potential Applications of Pharmacogenomics to Heart Failure Therapies. John Sutton. 5 mg, or 25 mg of carvedilol, twice daily). CrossRef 209 Amit Vora, Samhita Kulkarni. T. (2014) Electrophysiologic Therapeutics in Heart Failure in Adult Congenital Heart Disease. (2016) In Vitro Enhancement of Carvedilol Glucuronidation by Amiodarone-Mediated Altered Protein Binding in Incubation Mixture of Human Liver Microsomes with Bovine Serum Albumin. CrossRef 202 Akinyemi Oni-Orisan, David E. Adobe Flash Player is required to view this feature. (2014) Efficacy and safety of bisoprolol fumarate compared with carvedilol in Japanese patients with chronic heart failure: results of the randomized, controlled, double-blind, Multistep Administration of bisoprolol IN Chronic Heart Failure II (MAIN-CHF II) study. Adobe Flash Player is required to view this feature. Peter. (2011) Disparities in Women with Heart Failure. Chen, S. (2015) Efficacy and safety of supramaximal titrated inhibition of renin-angiotensin-aldosterone system in idiopathic dilated cardiomyopathy. M. (2012) Device Therapy to Modulate the Autonomic Nervous System to Treat Heart Failure. Forman, Ali Ahmed, Jerome L. (2013) Coronary CT Angiography Can Be Used As a Substitute for Coronary Angiography in Patients With Significant LV Dysfunction. (2012) Hyperkalaemia in the age of aldosterone antagonism. CrossRef 218, Dipak Kotecha, Luis Manzano, Douglas G Altman, Henry Krum, Guliz Erdem, Nicola Williams, Marcus D Flather. Aronow. In the analysis of mortality, data on patients were censored at the time of cardiac transplantation. Fonarow. Psotka, John R. 2014. Digitalis for treatment of heart failure in patients in sinus rhythm. Jankowska, Mariell Jessup, Cecilia Linde, Petros Nihoyannopoulos, John T. Patients assigned to the dose-ranging protocol were randomly assigned to one of four parallel treatment groups (placebo or 6. J. Min. Bress, Vicki Groo, Sahar Ismail, Grace Wu, Shitalben R. CrossRef 174 Mustafa Karabacak, Abdullah Dogan, Fatih Aksoy, Mehmet Ozaydin, Dogan Erdogan, Pinar Karabacak. Maron, Mark A. (2013) Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations. Lopshire, Douglas P. Floh, Osami Honjo, Jennifer Conway. Poppe, Nikki Earle, Iain Squire, Mark Richards, Bert Andersson, Justin A. (2016) The Future of Cardiac Imaging. Stolarz, Nancy J. (2012) Left ventricular dysfunction due to diffuse multiple vessel coronary artery spasm can be concealed in dilated cardiomyopathy. As a result, the duration of follow-up was short and fixed. Journal of the Chinese Medical Association 78, 1-47. CrossRef 360 Bilal Yilmaz, Duygu Ekinci. (2013) Reduced right ventricular ejection fraction and increased mortality in chronic systolic heart failure patients receiving beta-blockers: Insights from the BEST trial. Marrakchi, R. (2015) Treatment of Heart Failure in Real-World Clinical Practice: Findings From the REFLECT-HF Registry in Patients With NYHA Class II Symptoms and a Reduced Ejection Fraction. CrossRef 47 Wenqian Cai, Takayuki Fujita, Yuko Hidaka, Huiling Jin, Kenji Suita, Rajesh Prajapati, Chen Liang, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Satoshi Okumura, Yoshihiro Ishikawa. In the two multicenter studies, 19,20 treatment with metoprolol for 12 to 18 months or with bisoprolol for 4 to 44 months was associated with fewer hospitalizations for worsening heart failure and a reduced risk of clinical deterioration requiring cardiac transplantation. The duration of therapy ranged from 1 day to 15. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 140 Michel Komajda. Price. (2011) Influence of Global Region on Outcomes in Heart Failure Beta-Blocker Trials. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Zoghbi. Although several trials examining mortality in heart failure have also used a fixed follow-up period, 19,37 such a design necessarily reduces the number of events that can be observed. Blake Wachter, Edward M. Differences between treatment groups in post-randomization measures or events were evaluated by analysis of variance and with the chi-square statistic. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Paul Man, Don D. Journal of Molecular and Cellular Cardiology 55, 31-41. Knuuti, P. (2011) Pathways in Heart Failure Disease Management Across Socioeconomic Spectra. Today, the study remains a world-class epicenter for cutting-edge heart, brain, bone, and sleep research. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Blaxall. The American Journal of Medicine 126, 6-12. 2013. CrossRef 353 Kathy Hebert, Ilia Gogichaishvili, Stephanie Gopie, Lee Arcement. CrossRef 227 Chandralekha Bhagat, Sandeep Kumar Singh, Priya Ranjan Prasad Verma, Neeru Singh, Samridhi Verma, Mohd Neyaz Ahsan. (2013) Effect of chronic hypoxic hypoxia on oxidation and glucuronidation of carvedilol in rats. Costa-Neto. However, because carvedilol exerts pharmacologic effects atypical of and in addition to its action on adrenergic receptors, 22-24 experience with this drug does not allow us to conclude that all beta-blockers will favorably alter the natural history of this disorder. CrossRef 261 Mauricio Velez, Smita Kohli, Hani N. Wenger. (2016) Mental stress and human cardiovascular disease. Asian Pacific Journal of Cancer Prevention 15, 9567-9574. Waywell, C. Lavie, Ileana Pina. Waiting List Management for Heart Transplantation. Oh. Adobe Flash Player is required to view this feature. CrossRef 29 Ari Katz, Elad Maor, Jonathan Leor, Robert Klempfner. Narahari Sastry, Sanjay K. M. Coppler, Jennifer Katzianer, Randi Lynn Griffiths, Ivy Tonnu-Mihara, Paul Heidenreich. Zhang, Allen S. Ruskin. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Verrier. American Journal of Respiratory and Critical Care Medicine 187, 14-19. Adobe Flash Player is required to view this feature. The decrease in hospitalizations for cardiovascular causes seen with carvedilol in our study reaffirms these earlier observations. (2012) Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown. (2015) Genotype-based clinical trials in cardiovascular disease. Kamal, Burns C. (2012) A Consistency-Adjusted Strategy for Accommodating an Underpowered Primary Endpoint. (2015) Pharmacologic Options for the Management of Systolic Heart Failure: Examining Underlying Mechanisms. Allman, Ali Ahmed. Voors, F. Popescu, Z. Maher. CrossRef 313, John J. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine 10, 169-172. CrossRef 27 Thi Yen Loan Le, Sujitha Thavapalachandran, Eddy Kizana, James JH Chong. CrossRef 118 Michele Arcopinto, Andrea Salzano, Jorgen Isgaard, Antonio Cittadini. CrossRef 377 Thomas Yeoh, Christopher Hayward, Victoria Benson, Angela Sheu, Zara Richmond, Michael P. (2015) 1. (2015) ESC guidelines adherence is associated with improved survival in patients from the Norwegian Heart Failure Registry. CrossRef 201 Hiroshi HONMA, Tadaaki OHNO, Yukichi TOKITA, Tsuyako MATSUZAKI, Hiroyuki FUJIMOTO, Aya YOSHINAGA, Shoko SATO, Tomoko YOKOSHIMA, Keiko ITO, Kyoichi MIZUNO. Parker. Rutten, Juerg Schwitter, Petar Seferovic, Janina Stepinska, Pedro T. CrossRef 364 Elske Sieswerda, Elvira C van Dalen, Aleida Postma, Daniel KL Cheuk, Huib N Caron, Leontien CM Kremer, Elske Sieswerda. CrossRef 243 Madeline McCarren, Elaine Furmaga, Cynthia A. D. Aronow, Prakash Deedwania, Finn Waagstein, Ali Ahmed. e12. (2013) Metabolic Rates of ATP Transfer Through Creatine Kinase (CK Flux) Predict Clinical Heart Failure Events and Death. Journal of the American College of Cardiology 64, 253-255. Eighty percent of the patients received target doses of the study drugs. (2013) The 2012 Canadian Cardiovascular Society Heart Failure Management Guidelines Update: Focus on Acute and Chronic Heart Failure. CrossRef 63 Naoko Kumagai, Masahiro Ogawa, Bo Zhang, Rie Koyoshi, Joji Morii, Tomoo Yasuda, Naomichi Matsumoto, Kunihiro Matsuo, Keijiro Saku. (2013) Effectiveness of Chinese Herbal Medicine as an Adjunctive Treatment for Dilated Cardiomyopathy in Patients with Heart Failure. (2016) Pharmacological Modulation of Calcium Homeostasis in Familial Dilated Cardiomyopathy: An. Mann. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. L. , New York, NY 10032. 24 Yue T-L, Cheng H-Y, Lysko PG, et al. Sanderson. Guerra, Denis Roy. Kadish, Jeffrey J. Adobe Flash Player is required to view this feature. Nutritional and Integrative Strategies in Cardiovascular Medicine, 283-304. CrossRef 235 Genzou Takemura, Motoo Kanoh, Shinya Minatoguchi, Hisayoshi Fujiwara. Effect of flosequinan on survival in chronic heart failure: preliminary results of the PROFILE Study. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. H. G-Protein-Coupled Receptors in the Heart. Zuckerman. (2015) Drug therapies in older adults (part 2). (2013) Changes in parasympathetic system in medulla oblongata in male pigs in the course of tachycardia-induced cardiomyopathy. Sarnak. Rodgers, Carla A. (2016) Pathophysiologic Insights into Heart Rate Reduction in Heart Failure: Implications in the Use of Beta-Blockers and Ivabradine. The American Journal of Geriatric Pharmacotherapy 10, 69-80. (2014) The PREDICT (increasing the participation of the elderly in clinical trials) study: the charter and beyond. (2016) Paradoxical nocturnal elevation of sympathetic tone and spontaneous ventricular fibrillation in Brugada syndrome. Journal of the American College of Cardiology 61:12, 1259-1267. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Tendera, A. Eur Heart J (in press). Althouse, Samir Saba. Weeks, Adam Sieg, Jennifer Ann Gass, Indranee Rajapreyar. Accordingly, 1094 patients were randomly assigned to double-blind treatment: 398 with placebo and 696 with carvedilol. (2016) Diagnosis and treatment strategies for children with myocarditis. (2016) The evolution of medical therapy for children with heart failure. Adobe Flash Player is required to view this feature. Patients in the carvedilol group had a 65 percent lower risk of death than patients in the placebo group (P Article Activity 2050 articles have cited this article Article Activation of the sympathetic nervous system is one of the cardinal pathophysiologic abnormalities in patients with chronic heart failure. Murphy, Will Sauer, Michael R. K. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 122 O. Chatterjee, F. J. Sanchez, Stanley J. Hence, our study does not allow any conclusions to be drawn about the safety of carvedilol when it is administered without rigorous supervision or in bedridden patients with advanced heart failure. Jensen. A. The International Journal of Cardiovascular Imaging 31, 399-407. Mehra, Marc Pfeffer, Karl Swedberg, Jean-Claude Tardif. Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death. CrossRef 244 G. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2013) Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF). CrossRef 183 William B Hood, Jr. (2013) Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation. No patient was lost to follow-up with respect to mortality. Our finding that carvedilol reduces morbidity and mortality supports the hypothesis that a beta-blocker can favorably influence the course of disease in patients with heart failure. In addition, a major secondary objective of each of the component protocols was to evaluate the effect of carvedilol on cardiovascular morbidity, defined as hospitalization for heart failure or other cardiovascular causes. Leonard, R. Panni, Timothy J. Mohammad, Futwan Al-Mohanna. J. — Lovelace Scientific Resources, L. Beta-adrenergic receptor regulation and left ventricular function in idiopathic dilated cardiomyopathy. (2012) The human sympathetic nervous system: its relevance in hypertension and heart failure. Wu, S. Parkhomenko, B. CrossRef 147 Luisa Mestroni, Francesca Brun, Anita Spezzacatene, Gianfranco Sinagra, Matthew R. Vittorio. Appendix The following centers and principal investigators composed the U. (2015) Changes in Drug Utilization and Outcome With Cardiac Resynchronization Therapy: A MADIT-CRT Substudy. (2011) The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension. (2011) The role of beta-blockers in the treatment of chronic heart failure. DiNicolantonio, H. This limited experience restricts our ability to reach conclusions about the true magnitude or persistence of any effect on survival. Heart Failure (Stages A, B and C). Walkey. The question of whether other beta-blockers (such as metoprolol, bisoprolol, and bucindolol) prolong survival in heart failure is being addressed in ongoing trials. Adobe Flash Player is required to view this feature. Sueta. (2013) Peripartum Cardiomyopathy. Keogh, Peter Macdonald, Diane Fatkin. Jackson. CrossRef 170 E. Effect of vasodilator therapy on mortality in chronic congestive heart failure: results of a Veterans Administration Cooperative Study. CrossRef 77 Juan Carlos Kaski. CrossRef 327 Amresh Raina, Raymond L Benza. Rapoport, T. (2013) Treatment Strategies for the Prevention of Heart Failure. CrossRef 20 Yuk Law, David Rosenthal, Paul Kantor. Furthermore, our program recruited few patients with New York Heart Association class IV heart failure, 33 and patients who required hospitalization for intravenous drug support were not enrolled. El-Sawalhi. 2016. Heckman, Jeannine Costigan, Anique Ducharme, Estrellita Estrella-Holder, Nadia Giannetti, Adam Grzeslo, Karen Harkness, Jonathan G. (2017) Drug Therapy for Stable Angina Pectoris. 2017. 2011. (2014) Dynamic bias and its implications for GPCR drug discovery. It must be emphasized, however, that carvedilol therapy was initiated in the study with extreme care by physicians experienced in the management of heart failure, who followed specific guidelines that encouraged changes in concomitant medications to ensure the safety of the patient. CrossRef 252 Tatsunori Taniguchi, Tomohito Ohtani, Isamu Mizote, Machiko Kanzaki, Yasuhiro Ichibori, Hitoshi Minamiguchi, Yoshihiro Asano, Yasushi Sakata, Issei Komuro. Effects of vesnarinone on morbidity and mortality in patients with heart failure. (2012) A Personalized BEST: Characterization of Latent Clinical Classes of Nonischemic Heart Failure That Predict Outcomes and Response to Bucindolol. Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Friedman, Sana M. A. Ceconi, V. (2016) AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model. Dean, C. 1 months (median, 6. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Kjeldsen, Arne S. Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer. (2013) Frontiers of Therapy for Patients With Heart Failure. (2015) Bucindolol hydrochloride in atrial fibrillation and concomitant heart failure. (2014) Aortic valve calcification and increased stiffness of the proximal thoracic ascending aorta: association with left ventricular diastolic dysfunction and early chronic kidney disease. (2013) Sex and Gender Differences in Myocarditis and Dilated Cardiomyopathy. CrossRef 168 Howard J. Fortunately, the mortality rate during the two-week, open-label period was low (0. CrossRef 119 Ramineni Venkatesh, Suresh Kasaboina, Hanmant K. (2016) Circulating Procollagen Type III N-Terminal Peptide and Mortality Risk in African Americans With Heart Failure. Methods We enrolled 1094 patients with chronic heart failure in a double-blind, placebo-controlled, stratified program, in which patients were assigned to one of four treatment protocols on the basis of their exercise capacity. H. Van Veldhuisen. Stauffer, C. (2013) Heart Failure in Very Old Adults. V. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. CrossRef 191 Yutang Wang, Sai-Wang Seto, Jonathan Golledge. Although deaths may occur during the open-label period, they cannot be validly assigned to either the treatment or the placebo group, since they may be related either to the natural history of heart failure or to carvedilol. CrossRef 22 Wonshill Koh, Christina Wong, W. CrossRef 238 Raj Parikh, Philip J Kadowitz. Bax, H. CrossRef 241 Roberto Spoladore, Gabriele Fragasso, Gianluca Perseghin, Francesco De Cobelli, Antonio Esposito, Francesco Maranta, Giliola Calori, Massimo Locatelli, Guido Lattuada, Paola Scifo, Alessandro Del Maschio, Alberto Margonato. Neurobiology of Aging 32, 2321. Smith, Samuli Ripatti. (2015) Third-Generation Beta-Adrenoceptor Antagonists in the Treatment of Hypertension and Heart Failure. (2011) Would access to device therapies improve transplant outcomes for adults with congenital heart disease. (2011) Phosphatase-1 inhibitor-1 in physiological and pathological. CrossRef 125 Chin-Sheng Lin, Wei-Shiang Lin, Cheng-Li Lin, Chia-Hung Kao. (2013) Specialist initiation and monitoring of beta blockers in patients with chronic heart failure and concomitant obstructive airways disease. Sabbah. Farkouh, Charanjit S. No formal rules for stopping the trial were adopted before the initiation of enrollment. (2016) Management of Patients With Recovered Systolic Function. Denker, Debbie L. Most such trials are designed as long-term studies in which nonfatal events are considered to be secondary end points. 5 months). Padaria, Edmund P. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Journal of the American College of Cardiology 61:6, 643-644. This explains why, although the annual mortality in our placebo group (14 to 15 percent) was similar to that in many studies, 35,38 we recorded only 53 deaths (since the average follow-up was only 6. Pletcher. Deaton, R. CrossRef 319 Stephan Van Eeden, Jonathon Leipsic, S. (2013) Uptitration of Renin-Angiotensin System Blocker and Beta-Blocker Therapy in Patients Hospitalized for Heart Failure With Reduced Versus Preserved Left Ventricular Ejection Fractions. Taylor. CrossRef 23 Leah Raj, Bhavin Adhyaru. Carvedilol improves left ventricular function and symptoms in chronic heart failure: a double-blind randomized study. Kalogeropoulos, Javed Butler. CrossRef 369 Henry Krum, John R Teerlink. CrossRef 68 Emilie Jean-St-Michel, Devin Chetan, Steven M. Cheng, Dong Zhao. (2012) Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application. (2014) Genetic causes of dilated cardiomyopathy. 2014. Ventricular Tachycardia in Patients With Dilated Cardiomyopathy. Adobe Flash Player is required to view this feature. Bax, Helmut Baumgartner, Claudio Ceconi, Veronica Dean, Christi Deaton, Robert Fagard, Christian Funck-Brentano, David Hasdai, Arno Hoes, Paulus Kirchhof, Juhani Knuuti, Philippe Kolh, Theresa h, Cyril Moulin, Bogdan A. CrossRef 53 Paolo Palatini, Enrico Agabiti Rosei, Edoardo Casiglia, John Chalmers, Roberto Ferrari, Guido Grassi, Teruo Inoue, Bojan Jelakovic, Magnus T. (2015) Refractory hyperaldosteronism in heart failure is associated with plasma renin activity and angiotensinogen polymorphism. Yeh, Jack F. Adobe Flash Player is required to view this feature. Syeda, Renda Soylemez Wiener, Allan J. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Abstract Background Controlled clinical trials have shown that beta-blockers can produce hemodynamic and symptomatic improvement in chronic heart failure, but the effect of these drugs on survival has not been determined. CrossRef 378 Murray Esler. Sechtem, P. Shaddy. H. (2014) Aortic Counterpulsation: C-Pulse and Other Devices for Cardiac Support. (2016) Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome. Back, SR Wayne Chen, Peng-Sheng Chen. Kammoun, S. Altman, Jeremy N. (2012) Utilization and Costs of Cardiovascular Disease Medications in Dialysis Patients in Medicare Part D. T. CrossRef 13 Hiren Prajapati, Ramandeep Sharma, Dixit Patel. Nebivolol increases survival in cardiomyopathic hamsters with congestive heart failure. McMurray, Stamatis Adamopoulos, Stefan D. (2013) Effect of Race on Left Ventricular Ejection Fraction Decline After Initial Improvement with Beta Blockers in Patients with Non-Ischemic Cardiomyopathy: A Retrospective Analysis. FHS Newsletter 2016 - featuring an overview of the Upcoming Exam. Type simple information such as your age and weight into our calculators. Whalley, John J. (2013) Synthesis of N-methylcarbazoles from N-(2-iodoaryl)-N-methylanilines in the presence of potassium tert-butoxide and iron(II) bromide. Al-Sheklly, B. CrossRef 281 Kazuhiro Yamamoto, Hideki Origasa, Masatsugu Hori,. Adobe Flash Player is required to view this feature. (2013) Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design. (2015) Clinical Significance of High-Sensitivity Cardiac Troponin T in Patients With Dilated Cardiomyopathy. Adobe Flash Player is required to view this feature. For all four protocols, the dose was gradually adjusted upward to the target level over a period of 2 to 10 weeks, after which double-blind therapy was maintained for an additional 6 months (except in the mild-heart-failure protocol, in which patients were treated for an additional 12 months). Beneficial effects of metoprolol in heart failure associated with coronary artery disease: a randomized trial. (2013) The effect of carvedilol on serum and tissue oxidative stress parameters in partial ureteral obstruction induced rat model. Dickstein, Isabel Arrieta-Cruz, Wei Zhao, Xianjuan Qian, Ashley Lamparello, Rakesh Subnani, Mario Ferruzzi, Constantine Pavlides, Lap Ho, Patrick R. Athar, Kapil Parakh. Bertrand, Matthias Dupont, W. (2014) Effects of carvedilol on cardiac autonomic nerve activities during sinus rhythm and atrial fibrillation in ambulatory dogs. Calvert. CrossRef 276 Anastasios Lymperopoulos, Ashley Bathgate. Adobe Flash Player is required to view this feature. CrossRef 165 Francisco A Arabia, Jaime D Moriguchi. Mukhtar, S. Sirnes, M. Kfoury, Anji T. Stamos, Larisa H. (2013) Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility. Journal of Cardiovascular Pharmacology and Therapeutics 18:5, 412-426. Rusch. Bachmann. Citing Articles 1 Cosmo Godino, Antonio Colombo, Alberto Margonato. CrossRef 208 Yoichi Sunagawa, Shogo Sono, Yasufumi Katanasaka, Masafumi Funamoto, Sae Hirano, Yusuke Miyazaki, Yuya Hojo, Hidetoshi Suzuki, Eriko Morimoto, Akira Marui, Ryuzo Sakata, Morio Ueno, Hideaki Kakeya, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto. CrossRef 326 G. Jankowska, Mariell Jessup, Cecilia Linde, Petros Nihoyannopoulos, John T. Louis University Medical Center, L. Banerjee. (2013) Discharge heart rate and future events among Japanese patients with acute heart failure receiving beta-blocker therapy. (2016) Genetic Predispositions to Heart Failure. (2011) Cardiomyopathy and heart failure in children: anesthetic implications. (2016) The Prevention of Hospital Readmissions in Heart Failure. Adobe Flash Player is required to view this feature. Carvedilol Heart Failure Study Group: Albuquerque, N. Lewis. (2014) The influence of enalapril and spironolactone on electrolyte concentrations in Doberman pinschers with dilated cardiomyopathy. The beneficial effect of carvedilol on survival was consistent in all evaluated subgroups and was reflected in a decrease in the risk of death from progressive heart failure as well as in the risk of sudden death. Nguyen, Khalid Numan Al Azza, Hau Van Tran, Gianluca Rigatelli. (2017) Protective effects of bisoprolol against myocardial injury and pulmonary dysfunction in patients with chronic heart failure. Adobe Flash Player is required to view this feature. Reiner, U. Deedwania, Enrique Carbajal. CrossRef 59 Shinpei Kadowaki, Tetsuro Shishido, Yuki Honda, Taro Narumi, Yoichiro Otaki, Daisuke Kinoshita, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Tetsu Watanabe, Isao Kubota. (2013) Anti-inflammatory and pro-angiogenic effects of beta blockers in a canine model of chronic ischemic cardiomyopathy: comparison between carvedilol and metoprolol. Cardioskeletal Myopathies in Children and Young Adults, 39-64. (2016) Improving medication titration in heart failure by embedding a structured medication titration plan. CrossRef 138 Yuichi Baba, Toru Kubo, Shigeo Yamanaka, Takayoshi Hirota, Katsutoshi Tanioka, Naohito Yamasaki, Tetsuro Sugiura, Hiroaki Kitaoka. Motonaga, Paul Khairy, Anne M. CrossRef 64 Glauco Henrique Balthazar Nardotto, Eduardo Barbosa Coelho, Maria Paula Marques, Vera Lucia Lanchote. (2016) A Review of New Pharmacologic Treatments for Patients With Chronic Heart Failure With Reduced Ejection Fraction. Cavallari. Canty. Bax, Helmut Baumgartner, Claudio Ceconi, Veronica Dean, Christi Deaton, Robert Fagard, Christian Funck-Brentano, David Hasdai, Arno Hoes, Paulus Kirchhof, Juhani Knuuti, Philippe Kolh, Theresa McDonagh, Cyril Moulin, Bogdan A. Popescu, P. Shah. (2015) Inhibitory effect of ketoconazole and voriconazole on the pharmacokinetics of carvedilol in rats. Metabolic Cardiology: The Missing Link in the Treatment and Management of Heart Failure. In our program, however, the individual protocols were designed first to evaluate nonfatal end points as components of a single stratified trial program, and then mortality was specified a priori to assess safety and potential benefit. Sobotka, Horst Sievert. (2016) Current treatment of heart failure with reduction of left ventricular ejection fraction. Journal of the American College of Cardiology 62, e147-e239. Blauwet. (2011) Beta2-adrenergic receptor genotype influences the effect of nonselective vs. (2015) Hitting the Mark: Blood Pressure Targets and Agents in Those With Prevalent Cardiovascular Disease and Heart Failure. Sidhu, William E. (2016) Left ventricular reverse remodeling with infantile dilated cardiomyopathy and pitfalls of carvedilol therapy. (2015) Angiotensin Receptor Neprilysin Inhibition in Heart Failure: Mechanistic Action and Clinical Impact. Gaikwad, Sridhara Janardhan, Rajashaker Bantu, Lingaiah Nagarapu, G. Grodin, W. Adobe Flash Player is required to view this feature. Melnika, K. CrossRef 132 Konstantinos Tsioufis, George Andrikopoulos, Athanasios Manolis. Funck-Brentano, D. Dini. CrossRef 236 Yulin Liao, Jianping Bin, Tao Luo, Hui Zhao, Catherine Ledent, Masanori Asakura, Dingli Xu, Seiji Takashima, Masafumi Kitakaze. The U. Adobe Flash Player is required to view this feature. Ben Lamin, M. CrossRef 54 Noriko Kikuchi, Kentaro Jujo, Junichi Yamaguchi, Hiroshi Ogawa, Nobuhisa Hagiwara. Jankowska, Piotr Ponikowski. CrossRef 199 Minoru Tabata, Ryosuke Shimizu, Daisuke Kamekawa, Michitaka Kato, Kentaro Kamiya, Ayako Akiyama, Yumi Kamada, Shinya Tanaka, Chiharu Noda, Takashi Masuda. Lanfear. Fonarow, Javed Butler,. (2012) Beta-Blockers and Weight Change in Patients With Chronic Heart Failure. (2012) Carvedilol suppresses fatty acid oxidation and stimulates glycolysis in C2C12 cells. CrossRef 173 Peter Crome, Antonio Cherubini, Joaquim Oristrell. (2016) Measuring quality in electrophysiology. Adobe Flash Player is required to view this feature. CrossRef 115 Eric Black-Maier, Benjamin A Steinberg, Jonathan P Piccini. CrossRef 78 Makoto Sekimoto, Toru Takamori, Saki Nakamura, Masato Taguchi. CrossRef 233 Iosif Kelesidis, Patrick Hourani, Christopher Varughese, Ronald Zolty. Journal of the American Medical Directors Association 13, 448-452. Shaw. American Journal of Respiratory and Critical Care Medicine 186, 11-16.


Chapagain, N. Parker, John O. 2016. Weeda, C. Journal of the American College of Cardiology 58:11, 1112-1118. Antioxidant therapy associated with the reversal of oxidative stress delays the pathogenesis of heart failure. (2012) The Relationship between Lung Inflammation and Cardiovascular Disease. Chrigui, I. Al-Khatib. (2016) Cumulative subgroup analysis to reduce waste in clinical research for individualised medicine. (2013) Derivation of a mathematical expression for predicting the time to cardiac events in patients with heart failure: a retrospective clinical study. Cardioprotective effects of carvedilol, a novel beta adrenoceptor antagonist with vasodilating properties, in anaesthetized minipigs: comparison with propranolol. Adobe Flash Player is required to view this feature. (2013) Beneficial effects of beta-blockers on left ventricular function and cellular energy reserve in patients with heart failure. A. To enhance the safety of patients, therapy with carvedilol was initiated in small doses that were gradually increased over a period of several weeks. CrossRef 386 Angela Yee-Moon Wang, John E. Mark. Adobe Flash Player is required to view this feature. Harris, Stephen Kritchevsky, Clyde Yancy, Mihai Gheorghiade, Gregg C. -F. CrossRef 274 Michiel Rienstra, Kevin Damman, Bart A. (2016) Tolvaptan Improves the Long-Term Prognosis in Patients With Congestive Heart Failure With Preserved Ejection Fraction as Well as in Those With Reduced Ejection Fraction. Katkevics. CrossRef 192 Masatsugu Hori, Ryozo Nagai, Tohru Izumi, Masunori Matsuzaki. Apply to use Framingham data in your study. Sanoski, Sarah Hanigan, Robert J. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2012) Cochrane Review: Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer. Adobe Flash Player is required to view this feature. Patients in the carvedilol group had a 65 percent lower risk of death than patients in the placebo group (P ). CrossRef 172 Philippe Gabriel Steg, Ranil De Silva. (2013) CB1 cannabinoid receptor deficiency promotes cardiac remodeling induced by pressure overload in mice. The Journal of Heart and Lung Transplantation 30, 395-401. CrossRef 50 Jay N. (2011) Efficacy of ivabradine in idiopathic dilated cardiomyopathy patients with chronic heart failure. CrossRef 41 Ares Pasipoularides. van Meurs, Kenneth B. Sin. (2014) Pharmacotherapy to reduce arrhythmic mortality. (2013) Strategies to Prevent Postdischarge Adverse Events Among Hospitalized Patients with Heart Failure. Huque, Mohamed Alosh. (2014) A nurse-led up-titration clinic improves chronic heart failure optimization of beta-adrenergic receptor blocking therapy - a randomized controlled trial. Towbin, John L. (2016) New Developments in Cardiac Regeneration. Goldstein. (2012) In-Hospital Cardiology Consultation and Evidence-Based Care for Nursing Home Residents With Heart Failure. (2016) Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction. (2016) Trends in hospitalization for congestive heart failure, 1996-2009. Anderson. (2012) Independent and Incremental Value of Severely Enlarged Left Atrium in Risk Stratification of Very Elderly Patients With Chronic Systolic Heart Failure. A. Hlatky. Patients who could tolerate 6. Book, Robert E. CrossRef 130 Teruhiko Imamura, Koichiro Kinugawa, Daisuke Nitta, Takeo Fujino, Toshiro Inaba, Hisataka Maki, Masaru Hatano, Osamu Kinoshita, Kan Nawata, Shunei Kyo, Minoru Ono. Morrison, B. CrossRef 169 Arun Kannan, Rajesh Janardhanan. (2014) Angiotensin II, sympathetic nerve activity and chronic heart failure. Williams, S. (2016) Impact of left ventricular ejection function on blood pressure-lowering therapy in hypertensive patients with coronary artery disease. Smith, Wengen Chen, Vasken Dilsizian, Timm Dickfeld. Adobe Flash Player is required to view this feature. Zeiher,, J. Weiss. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 289 Satoru Ohshima, Satoshi Isobe, Daisuke Hayashi, Shinji Abe, Katsuhiko Kato, Toyoaki Murohara. G. CrossRef 213 P. Adobe Flash Player is required to view this feature. CrossRef 376 Johanna Schneider, Achim Lother, Lutz Hein, Ralf Gilsbach. (2015) Design and synthesis of 3-(3-((9H-carbazol-4-yl)oxy)-2-hydroxypropyl)-2-phenylquinazolin-4(3H)-one derivatives to induce ACE inhibitory activity. Ben Lamin, Michele Brignole, Antonio Coca, Peter Cowburn, Henry Dargie, Perry Elliott, Frank Arnold Flachskampf, Guido Francesco Guida, Suzanna Hardman, Bernard Iung, Bela Merkely, Christian Mueller, John N. Ashman. Adobe Flash Player is required to view this feature. Journal of the American College of Cardiology 64, e77-e137. 2017. 5 months and extended to 15 months. (2016) Recent updates on GPCR biased agonism. Miyamoto, B. CrossRef 43 Manami Kaneko, Tomoko Satomi, Shuji Fujiwara, Hidefumi Uchiyama, Keiji Kusumoto, Tomoyuki Nishimoto. CrossRef 101 Antonio Carlos Pereira-Barretto. (2013) Current practice on the management of acute coronary syndrome in China. Schwinger, Klara Brixius. (2012) Heart Failure in Hypertension. (2011) Medical therapy for chronic heart failure. (2016) Oxygen uptake efficiency slope and peak oxygen consumption predict prognosis in children with tetralogy of Fallot. Kamphuisen, Johannes J. (2012) Emerging therapies for pulmonary arterial hypertension: a review of recently completed and ongoing clinical trials. (2015) Pathophysiologic and Treatment Strategies for Cardiovascular Disease in End-Stage Renal Disease and Kidney Transplantations. Hence, when a large clinical trial program with carvedilol in heart failure was being designed in 1992, we prospectively defined an overall objective of the program to be an evaluation of the effect of the drug on survival. 2016. Mathew, Udho Thadani. Ben Lamin, Michele Brignole, Antonio Coca, Peter Cowburn, Henry Dargie, Perry Elliott, Frank Arnold Flachskampf, Guido Francesco Guida, Suzanna Hardman, Bernard Iung, Bela Merkely, Christian Mueller, John N. Fallaw, C. Baker. Bringis, M. J. Teerlink. Adobe Flash Player is required to view this feature. 6 percent) and was similar to — if not less than — the rate in the preceding three weeks (1. (2014) Convergence in findings from randomized trials and elaborately analysed observational data on mortality reduction with carvedilol in heart failure in comparison with metoprolol. 2016. Vittorio. Coppinger, C. CrossRef 176 Anasua Chakraborty, Saurav Chatterjee. CrossRef 215 Justin L. Canadian Journal of Physiology and Pharmacology 90, 1087-1093. Statistical Analysis The base-line characteristics of the two treatment groups were compared with use of the t-test and the chi-square statistic. McMurray. (2014) Pharmacogenomics in Heart Failure. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Jefferies, T. Lin, P. 2014. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 228 Giovanni Cioffi, Andrea Mortara, Andrea Di Lenarda, Fabrizio Oliva, Donata Lucci, Michele Senni, Giuseppe Cacciatore, Alessandra Chinaglia, Luigi Tarantini, Marco Metra, Aldo Pietro Maggioni, Luigi Tavazzi. Boden. (2014) Both Carvedilol and Nebivolol May Improve Platelet Function and Prothrombotic State in Patients With Nonischemic Heart Failure. CrossRef 384 Sherief Mansour, Amr Youssef, Mona Rayan, M. (2013) Effects of carvedilol treatment on cardiac cAMP response element binding protein expression and phosphorylation in acute coxsackievirus B3-induced myocarditis. A. (2013) A review of current therapies used in the treatment of congestive heart failure. Kolh, T. -K. (2014) Heart rate awareness in patients with chronic stable heart failure. Lonigro, and H. CrossRef 250 Shizuka Yamaura, Miki Fukao, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto. (2014) Prevalence of Guideline-Directed Medical Therapy Among Patients Receiving Cardiac Resynchronization Therapy Defibrillator Implantation in the National Cardiovascular Data Registry During the Years 2006 to 2008. Wilson Tang, Wilfried Mullens. Sekar, T. Adobe Flash Player is required to view this feature. L. Antiarrhythmic Drugs. The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure. Our findings should be interpreted with the knowledge that the trial program had several unusual characteristics for a study of the effect of a drug on survival. G. Atherton. (2011) Voltammetric behavior of carvedilol in non-aqueous media and its analytical determination in pharmaceutical preparations. (2015) Effects of early and late-onset treatment with carvedilol in an experimental model of aortic regurgitation. 2012. Fallavollita, John M. CrossRef 332 Ben W. (2016) Addition of beta-blockers to digoxin is associated with improved 1- and 10-year survival of patients hospitalized due to decompensated heart failure. 2015. Theuns, Tamas Szili-Torok. D. (2013) Pericarditis, Myocarditis, and Other Cardiomyopathies. CrossRef 358 Emmae N Ramsay, Elizabeth E Roughead, Ben Ewald, Nicole L Pratt, Philip Ryan. Esler. Bogaard, Anton Vonk-Noordegraaf. CrossRef 127 J. (2014) A pathway and network review on beta-adrenoceptor signaling and beta blockers in cardiac remodeling. Rutten, J. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2011) Chronic Heart Failure. Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. However, since it was anticipated (on the basis of earlier studies) that carvedilol could reduce mortality, all statistical analyses were two-sided. In addition, carvedilol therapy was associated with a 26 percent reduction in hospitalization for cardiovascular causes, a 38 percent decrease in the risk of death or hospitalization, and a lower rate of withdrawal from the trial due to worsening heart failure. Cohn. Lipworth. Berman, James K. Alexis. Coyne. (2014) Adrenergic signaling in heart failure: a balance of toxic and protective effects. Street, Brian C. 2015. Mc Donald, V. (2013) Reappraisal of increasing heart rate for cardiac performance. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Kjeldsen, Giuseppe Mancia, Gianfranco Parati, Paolo Pauletto, Andrea Stella, Alberto Zanchetti. McDonagh, C. CrossRef 85 Andrea Driscoll, Judy Currey, Andrew Tonkin, Henry Krum, Andrea Driscoll. CrossRef 114 Justin Penn, Ilan Goldenberg, Scott McNitt, Bronislava Polonsky, Martin H. S. Alternatively, the effects of carvedilol on survival may differ from those of other beta-blockers. Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy. CrossRef 82 Takashi Nakamura, Takayuki Fujita, Megumi Kishimura, Kenji Suita, Yuko Hidaka, Wenqian Cai, Masanari Umemura, Utako Yokoyama, Masami Uechi, Yoshihiro Ishikawa. (2015) Pathophysiological basis of myocardial innervation imaging in heart failure. J. Mancia, G. CrossRef 153 Haiwen Yu, Min Tang, Jun Yu, Xiaohong Zhou, Lepeng Zeng, Shu Zhang. CrossRef 37 Daniel KL Cheuk, Elske Sieswerda, Elvira C van Dalen, Aleida Postma, Leontien CM Kremer, Daniel KL Cheuk. Bottomley, G. (2016) An evidence-based review of recent advances in therapy for heart failure with reduced ejection fraction (HFrEF). CrossRef 100 Matteo Bauckneht, Gianmario Sambuceti, Elena Pomposelli, Francesco Fiz, Cecilia Marini. Bond. CrossRef 74 Anupam Basuray, James C. Journal of Molecular and Cellular Cardiology 101, 145-155. CrossRef 87 Kristian Eskesen, Niels Thue Olsen, Veronica L Dimaano, Thomas Fritz-Hansen, Peter Sogaard, Theodore P Abraham. selective beta-blockade on baroreflex function in chronic heart failure. CrossRef 338 Anastasios Lymperopoulos, Ashley Bathgate. CrossRef 89 Zheng He, Yun Sun, Hui Gao, Jun Zhang, Yuhong Lu, Jihua Feng, Hongli Su, Chao Zeng, Anlin Lv, Kang Cheng, Yan Li, Huan Li, Ronghua Luan, Ling Wang, Qiujun Yu. Pharmacologic Management of Heart Failure in the Ambulatory Setting. CrossRef 133 Sushma Reddy, Alan Fung, Cedric Manlhiot, Elif Seda Selamet Tierney, Wendy K. Fares, A. CrossRef 139 Tsuyoshi SHIGA. CrossRef 242 Finn Olav Levy. CrossRef 305 John J. Gilbert. Elizabeth Le, Marco Pascotto, Howard Leong-Poi, Ibrahim Sari, Antonio Micari, Sanjiv Kaul. (2014) Trial to Assess Chelation Therapy (TACT) and equipoise: When evidence conflicts with beliefs. CrossRef 184 Xian-Bing Gan, Hai-Jian Sun, Dan Chen, Ling-Li Zhang, Hong Zhou, Li-Yan Chen, Ye-Bo Zhou, Michael Bader. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Jackson, Nanette K. Whooley, Thomas D. Cardiac Sympathetic Innervation and Ablation of Ventricular Tachycardia. Boxall, Andrew L. (2012) Evidence-Based Therapy for Heart Failure. (2014) Optimal Dose-Setting Study of Curcumin for Improvement of Left Ventricular Systolic Function After Myocardial Infarction in Rats. Packer at the Division of Circulatory Physiology, Columbia University College of Physicians and Surgeons, 630 W. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 224 (2013) 2013 ESC guidelines on the management of stable coronary artery disease. Goldberger. The American Journal of Medicine 126, 805-810. Parreiras-e-Silva, Claudio M. Journal of the American College of Cardiology 64, 2373-2405. CrossRef 15 Annabel Hickey, Jessica Suna, Louise Marquart, Charles Denaro, George Javorsky, Andrew Munns, Alison Mudge, John J. (2013) Traditional Heart Failure Medications and Sudden Cardiac Death Prevention: A Review. Patients were observed for the occurrence of death or hospitalization for cardiovascular reasons during the following 6 months (12 months for the group with mild heart failure). CrossRef 221 Makoto Akaishi. 2012. Patients in the carvedilol group had a 38 percent lower risk of death or hospitalization for cardiovascular disease than patients in the placebo group (P ). (2015) Hormone replacement therapy in heart failure. (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. (2015) Gender Differences in Cardiovascular Drugs. CrossRef 84 Mihran Martirosyan, Dominic A. 2013. (2011) Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure. (2016) The role of pharmacotherapy in the prevention of sudden cardiac death in patients with heart failure. Cohn. This cautious approach has been followed in studies of other beta-blockers 12-20,34 and is designed to minimize the adverse effects that may occur after the abrupt withdrawal of the homeostatic support provided by the sympathetic nervous system. Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 46 Yun-Jeng Tsai, Min-Hui Li, Wan-Jung Tsai, Sheng-Hui Tuan, Tin-Yun Liao, Ko-Long Lin. CrossRef 219 Ge Li-Sha, Chen Yi-He, Zhou Na-Dan, Zhang Teng, Li Yue-Chun. (2012) Hospital compliance with performance measures and 30-day outcomes in patients with heart failure. (2014) Nebivolol: Vasodilator Properties and Evidence for Relevance in Treatment of Cardiovascular Disease. Prolongation of survival in congestive cardiomyopathy by beta-receptor blockade. 20 In contrast, in our study, carvedilol therapy was associated with a decrease in mortality, and the benefits of the drug were apparent in all the subgroups we examined, including patients with underlying ischemic heart disease. A. (2016) Comparative effects of nebivolol and carvedilol on left ventricular diastolic function in older heart failure patients with preserved ejection fraction: study protocol for a randomized controlled trial. Chine, A. CrossRef 239 M. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. 7 percent), during which patients were being screened for the program but were receiving only their usual medications for heart failure. Moulin, B. CrossRef 75 Boback Ziaeian, Gregg C. (2011) Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis. Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Effect of oral milrinone on mortality in severe chronic heart failure. CrossRef 95 Joanne Simpson, Davide Castagno, Rob N. Al Chekakie. Stable Ischemic Heart Disease Stable Ischemic Heart Disease. CrossRef 247 I. e1-2321. (2013) Clinical features, and in-hospital and 1-year mortalities of patients with acute heart failure and severe renal dysfunction. Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine: relation to pathogenesis of catecholamine cardiomyopathy. (2016) Current treatment of hypertension in patients with coronary artery disease recommended by different guidelines. Westheim. V. Hoppel. Fisker, Daniela Grimm, Markus Wehland. V. Arrestins in the Cardiovascular System. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. (2013) Cardiac sympathoexcitation in heart failure. CrossRef 93 Neerod Kumar Jha, Laszlo Kiraly, Csaba Tamas, Haitham Talo, Mohammad Daud Khan, Hazem El Badaoui, Anurag Jain, Azzam Hammad. Adobe Flash Player is required to view this feature. CrossRef 18 Fujian Song, Max O. (2015) Trimetazidine and Cardioprotection. CrossRef 179 Vaidehi J Thanawala, Gloria S Forkuo, Wayne Stallaert, Paul Leff, Michel Bouvier, Richard Bond. The Kaohsiung Journal of Medical Sciences 29, 19-25. Eisen. (2015) Prognostic Significance of Imaging Myocardial Sympathetic Innervation. (2014) Engaging Heart Failure Clinicians To Increase Palliative Care Referrals: Overcoming Barriers, Improving Techniques. (2014) Comparison of the clinical outcome of different beta-blockers in heart failure patients: a retrospective nationwide cohort study. Wilson Tang. Trindade, A. (2016) Effects of the inverse alpha-agonist doxazosin in allergic rhinitis. CrossRef 212 Melanie Turco Gura, William R. (2015) Neprilysin Inhibition in Heart Failure with Reduced Ejection Fraction: A Clinical Review. Wong, William A. Dudrick. Grassi. Niazi, S. (2015) Antihypertensive Medications in End-Stage Renal Disease. CrossRef 67 Takeshi Kitai, W. CrossRef 6 I. Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy. M. (2014) New Drugs and Devices in the Pipeline for Heart Failure with Reduced Ejection Fraction Versus Heart Failure with Preserved Ejection Fraction. Rutten, Juerg Schwitter, Petar Seferovic, Janina Stepinska, Pedro T. CrossRef 3 Catherine Gebhard. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Janosko, John Gorcsan, Kevin E. (2013) Mitochondria in cardiac hypertrophy and heart failure. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Cooper, Lori A. In the single-center study, 18 treatment with carvedilol for four months reduced the risk of cardiovascular events. Journal of the American College of Cardiology 60:24, 2564-2603. C. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. O. Cardioskeletal Myopathies in Children and Young Adults, 85-111. (2013) Switching from carvedilol to bisoprolol ameliorates adverse effects in heart failure patients with dizziness or hypotension. Arab, Maha M. DiDomenico. Adobe Flash Player is required to view this feature. Kip, G. Adobe Flash Player is required to view this feature. (2012) New Insights into Mechanisms of Action of Carvedilol Treatment in Chronic Heart Failure Patients—A Matter of Time for Contractility. CrossRef 175 Anthony J. 168th St. Stepinska, P. V. (2016) Emerging Therapies for Acute and Chronic Heart Failure. CrossRef 69 Etsuko Tsuda, Jun Negishi, Kanae Noritake, Toru Iwasa, Tadaaki Abe. (2014) Incident heart failure in relation to vascular disease: Insights from the Health, Aging, and Body Composition Study. Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Nurse-led titration of angiotensin converting enzyme inhibitors, beta-adrenergic blocking agents, and angiotensin receptor blockers for people with heart failure with reduced ejection fraction. S. (2014) Chronic vagus nerve stimulation improves left ventricular function in a canine model of chronic mitral regurgitation. (2016) Management of the hypertensive patient with elevated heart rate. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. e5. Hoes, Paulus Kirchhof, Juhani Knuuti, Philippe Kolh, Patrizio Lancellotti, Ales Linhart, Petros Nihoyannopoulos, Massimo F. Varosy. Masoudi, Paul D. (2014) Six-Minute Walk Distance Is an Independent Predictor of Hospital Readmission in Patients With Chronic Heart Failure. (2016) Vidarabine, an Anti-Herpes Virus Agent, Protects Against the Development of Heart Failure With Relatively Mild Side-Effects on Cardiac Function in a Canine Model of Pacing-Induced Dilated Cardiomyopathy. (2015) Is heart rate a risk marker in patients with chronic heart failure and concomitant atrial fibrillation. (2014) Hypertension as a Risk Factor for Heart Failure. Nurse-led titration of angiotensin converting enzyme inhibitors, beta-adrenergic blocking agents and angiotensin receptor blockers for patients with left ventricular systolic dysfunction. (2011) Nutritional Considerations in Adult Cardiothoracic Surgical Patients. Davis, Michael R. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Gislason, Christian Torp-Pedersen. (2011) Cardiovascular Disease in the Elderly. CrossRef 12 Shigeru Toyoda, Akiko Haruyama, Shu Inami, Hirohisa Amano, Takuo Arikawa, Masashi Sakuma, Shichiro Abe, Atsushi Tanaka, Koichi Node, Teruo Inoue. Allman, Ali Ahmed. Choi, M. CrossRef 80 Teruhiko Imamura, Koichiro Kinugawa. (2014) Beta-Blockers in Asymptomatic Coronary Artery Disease. CrossRef 19 Wilbert S. CrossRef 79 Hirotaka EZAKI, Takafumi INOKUCHI, Masanori TANIWAKI, Hirosada YAMAMOTO, Hiroshi DOI, Takayuki MIYAKE, Masami SAKURADA. (2016) Neurohormonal activation in heart failure with reduced ejection fraction. Wilson Tang. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. St. (2013) Myocardial 123I-MIBG scintigraphy predicts an impairment in myocardial functional reserve during dobutamine stress in patients with idiopathic dilated cardiomyopathy. (2014) Using beta-blockers to treat heart failure. (2016) Effect of aliskiren and carvedilol on expression of Ca. CrossRef 200 Andrea Driscoll, Piyush Srivastava, Deidre Toia, Jackie Gibcus, David L Hare. Devices for Heart Failure: Implantable Cardioverter Defibrillator. Najjar, A. Yetman. CrossRef 120 Stephen Sinatra. (2013) Beta-Blockers and Outcome in Heart Failure and Atrial Fibrillation. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Herzog, Wendy L. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. 2013. CrossRef 116 Giuseppe Vergaro, Cinzia Fatini, Elena Sticchi, Cristina Vassalle, Gianfranco Gensini, Andrea Ripoli, Patrick Rossignol, Claudio Passino, Michele Emdin, Rosanna Abbate. (2015) Beta-Blockers in Acute Heart Failure. -S. Bristow. Kosmas, Gabriel Wagman, Timothy J. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 32 Murray Esler. (2013) Comparative Effectiveness Research in Heart Failure Therapies. Cohen. (2014) Time and Technology Will Tell. Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger. CrossRef 265 Rine Nakanishi, Hyung Bok Park, Reza Arsanjani, Daniel S. Adobe Flash Player is required to view this feature. Adobe Flash Player is required to view this feature. Thus, most patients were able to tolerate target doses of carvedilol. (2017) Imaging of cardiac sympathetic activity in heart failure: Not out of the woods yet. CrossRef 234 Jaekyu Shin, Mark J. CrossRef 357 Jun Wang, Kenjiro Ono, Dara L. Jefferies. (2016) Chiral analysis of carvedilol and its metabolites hydroxyphenyl carvedilol and O-desmethyl carvedilol in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical pharmacokinetic study. G. Lefi. The International Journal of Cardiovascular Imaging 30, 1279-1287. (2013) Improvement of Guideline Beta-Blocker Prescribing in Heart Failure: A Cluster-Randomized Pragmatic Trial of a Pharmacy Intervention. Givertz, Jay N. (2011) Treatment of Heart Failure in Long-term Dialysis Patients: A Reappraisal. Berman, Ginger Biesbrock, Jeffrey Brinker, David Brophy, Manuel Cerqueira, Kavitha Chinnaiyan, Meryl Cohen, Vasken Dilsizian, Pamela S. Miller, S. Journal of Pharmaceutical and Biomedical Analysis 115, 359-367. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Parissis, Piotr Ponikowski. 2015. (2011) Clinical and Demographic Predictors of Outcomes in Recent Onset Dilated Cardiomyopathy. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Tanju Ozcelikay. (2014) Machines versus medication for biventricular heart failure: focus on the total artificial heart. Boden. CrossRef 72 Wilbert S Aronow. Wilson Tang. (2014) Medical Therapy in Adults with Congenital Heart Disease. 25 mg, 12. The Journal of Alternative and Complementary Medicine 19, 811-819. Jennison, A. Adobe Flash Player is required to view this feature. S. CrossRef 303 Takumi Inami, Masaharu Kataoka, Nobuhiko Shimura, Haruhisa Ishiguro, Hideyasu Kohshoh, Hiroki Taguchi, Ryoji Yanagisawa, Yukiko Hara, Toru Satoh, Hideaki Yoshino. Ronnevik, F. Strunz, Ulrich Tebbe. Yancy, Mariell Jessup, Biykem Bozkurt, Javed Butler, Donald E. Adobe Flash Player is required to view this feature. Journal of the American Academy of Physician Assistants 27, 50-55. H. CrossRef 290 Kazuki Oshima. Lai, G. (2014) Ligand bias prevents class equality among beta-blockers. (2015) Beta-blocker Use and 30-day All-cause Readmission in Medicare Beneficiaries with Systolic Heart Failure. 2012. CrossRef 7 S. H. (2016) Calcific Aortic Valve Disease: Part 2—Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility. A. Fagard, C. van Lieshout. (2015) Epidemiological trends in invasive mechanical ventilation in the United States: A population-based study. Mann, Blase Carabello. (2016) Clinical Phenotypes of Fontan Failure: Implications for Management. Primary Care: Clinics in Office Practice 40, 213-236. (2013) Individualization of Antihypertensive Drug Treatment. Kazi, Daniel B. 5 months). CrossRef 146 Amresh Raina, Manreet Kanwar. (2012) Assessment of Ventricular Remodeling in Heart Failure Clinical Trials. CrossRef 367 Giuseppe Marazzi, Maurizio Volterrani, Giuseppe Caminiti, Luigi Iaia, Rosalba Massaro, Cristiana Vitale, Barbara Sposato, Giuseppe Mercuro, Giuseppe Rosano. Uitterlinden, Manolis Kellis, Joyce B. Fonarow, Prakash Deedwania, Javed Butler, Peter Carson, Thomas E. Rosenthal, Gregory B. A. CrossRef 48 SP Wyles, SC Hrstka, S Reyes, A Terzic, TM Olson, TJ Nelson. A data and safety monitoring board was constituted before recruitment began, met periodically to review the unblinded results, and was empowered to recommend early termination of the program if its members observed a clinically important treatment effect. Dilated Cardiomyopathy and Cardioskeletal Involvement. (2012) The Neurohormonal Network in the RAAS Can Bend Before Breaking. CrossRef 343 Dobromir Dobrev, Bramah N. (2015) Large cardiac fibroma and teratoma in children- case reports. W. Cardiac Resynchronization Therapy. Kirchhof, J. Adobe Flash Player is required to view this feature. Despite such care, however, the frequency of early side effects was expected to be high enough potentially to unblind both the patient and the investigator as to the treatment-group assignment. McMurray, Stamatis Adamopoulos, Stefan D. CrossRef 255 Rafik Tadros, Paul Khairy, Jean L. CrossRef 163 Jessup, Mariell,. CrossRef 109 Harsh Golwala, Ambarish Pandey, Christine Ju, Javed Butler, Clyde Yancy, Deepak L. F. (2012) Renal Denervation for Hypertension. Gerstenblith, R. Yet previous trials in heart failure have not demonstrated a reduction in mortality during beta-blockade. (2013) Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: Modulation of oxidative stress and inflammatory mediators. If you are using an operating system that does not support